Epilepsy: A Comprehensive Textbook
2nd Edition

G
G-protein-coupled receptor (GPR56) gene
in bilateral polymicrogyria
GABA transporters (GATs)
genes
zonisamide and
GABAA-receptor complex (GRC)
estrous cycle and
GABAA receptor gene
Gabaculine
GABA blockade and
GABAergic transmission
chloride transporter and
Gabapentin
adverse effects
aggravation of myoclonus
in children
CNS symptoms
cosmetic
effect on hepatic porphyria
psychiatric
teratogenicity
weight gain
animal studies
Ca channel binding sites
chemical structure
in community-dwelling elderly
contraindications
in developing countries
discovery of
dosage recommendations
drug interactions
with oral contraceptives
pharmacodynamic
drug-metabolizing enzymes
effects on transcranial magnetic stimulation
efficacy
in acute metabolic crises
comparisons
in elderly patients
in generalized seizures
in HIV/AIDS
in juvenile myoclonic epilepsy (JME)
in migraine
in partial seizures
provoked seizures and
for refractory epilepsy
in simple motor seizures
fetal accumulation of
formulations
hepatic metabolism of
history of
in lactation
lamotrigine compared with
licensing process
mechanisms of action
in nursing homes
pharmacokinetics
absorption
in adults
drug interactions
in elderly patients
elimination
excretion
plasma protein binding
pregabalin compared with
in pregnancy
retention rate for
safety of
side effects
sleep architecture and
structure
therapeutic drug monitoring of
trials
withdrawal of
Gabapentin Pregnancy Registry
Gabitril See Tiagabine
Gabrab1 genes
Gabrab2 genes
Gabrab3 genes
Gabrb1 genes
Gabrb2 genes
GABRD genes
GABRG1 genes
GABRG2 genes
Gain of function mutations
Galactocerebrosidase deficiency
Galactose-1-phosphate uridyltransferase deficiency
Galactosemia
Galactosialodosis
β-Galactosidase deficiency
Galen
Galvani, Luigi
Galvanic skin reflex See Electrodermal (EGD) responses
Galvanometers
γ-Butyrolactone (GBL)
Gamma-glutamyltranspeptidase (GTT) levels
Gamma-hydroxybutyric acid
Gamma Knife radiosurgery (GKS)
in arteriovenous malformations
description
in hypothalamic hamartoma
in mesial temporal lobe epilepsy
outcomes
in sensory seizures
γ-Aminobutyric acid (GABA)
abnormalities
blockade
cortical excitability and
as excitatory neurotransmitter
in generalized spike-and-wave activity
inhibitory synaptic transmission by
levels
metabolic disorders
metabolism
postsynaptic response
potentiation of
release during seizures
seizure activity and
spectroscopic measurement of
subunit composition
synaptic transmission and
transplantation of cells producing
uptake inhibition
γ-Aminobutyric acid (GABA) receptors
affinity for GABA
alterations
antiepileptic drugs and
function of
GABAA
anatomic distribution
channel gating and
desensitization of
GABA binding site
molecular biology
pharmacology
physiology
structure
GABAB
activation of
anatomic distribution
antagonists
molecular biology
pharmacology
physiology of
trafficking
GABRD gene variant R220H
in kindling models
potentiation of
γ-Aminobutyric acid transaminase
γ-Glutamyltransferase (gamma-GT)
γ-Hydroxybutyrate
Ganaxolone (CCD 1042)
adverse effects
animal studies
chemistry
drug interactions
efficacy
pharmacokinetics
pharmacology
structure
tolerability
Ganciclovir, provoked seizures and
Gangliogliomas (GGs)
CT appearance
epilepsy and
epileptogenic potential of
growth rates of
immunohistochemistry
lesionectomy
MRI findings
resection
surgical interventions
Ganglioneuroblastomas
Gangliosides
Gangliosidosis
in early infancy
GM2
startle epilepsy and
Gap junctions
astrocyte
glial syncytium and
immature brain
neocortical neurons
in neurocortical seizures
proteins, neoplasms and
Garlic, safety issues
Gastaut, Henri
Gastaut-Geschwind syndrome See Interictal behavior syndrome
Gastaut-type childhood occipital epilepsy
Gastrodia elata
Gastroesophageal reflux (GER)
Gastrointestinal activity monitoring
Gastrointestinal diseases
Gating inputs, definition
Gaucher disease
Gel diffusion assays
Gelastic epilepsy
first description
hypothalamic hamartoma and
surgical interventions in
Gelastic seizures (GS)
asymmetric tonic seizures
clinical features
definitions
description
diagnosis
differential diagnosis
electroencephalographic findings
epidemiology
hypothalamic hamartoma and
specific syndromes
treatment
Gelfilm, use of
Gender
acute symptomatic seizures and
continuous spikes-and-waves in slow sleep syndrome and
conversion disorder and
drug treatment issues
emotional stress and
epilepsy prevalence and
health-related quality of life, perception of
incidence of epilepsy and
P.I-24

juvenile myoclonic epilepsy and
Landau-Kleffner syndrome and
levetiracetam elimination and
mental retardation, prevalence
presylvian site localization
prevalence of epilepsy and
psychoses in epilepsy and
social skills and
violence and
visual-induced seizures and
Gene expression
as AED target
basic principles
candidate genes
global analysis of
methodology
overview
network excitability and
ontology
patterns of
in response to seizures
in response to status epilepticus
profiling
Gene therapy
delivery methods
epilepsy treatment
genetically modified cells
nonviral delivery systems
outcomes
therapeutic targets
GeneChips
Gene–environment interactions
General anesthetics
General Equivalency Diplomas
Generalized absence epilepsy
animal models of
definitions
ILEA classification
interictal/ictal transitions
pharmacologic profile
spike-and-wave discharges in
Generalized anxiety disorders
anxiety disorders and
interictal
pharmacotherapy
psychogenic nonepileptic seizures and
Generalized atonic seizures
Generalized clonic seizures
anatomic pathways
clinical features
definitions
diagnostic considerations
electroencephalographic features
epidemiology
pathophysiology
specific syndromes
treatment
Generalized conditions, definitions
Generalized convulsive seizures
definition
effect on fetal heart rates
genes linked to
HIV and
hormone changes following
transitory changes following
Generalized convulsive status epilepticus (GCSE)
clinical features
definitions
diagnosis
differential diagnosis
“electrical”
epidemiology
etiology
pathophysiology
prognosis
treatment
Generalized epilepsies See also Generalized seizures
definitions
interictal EEGs
intractable
myoclonic status epilepticus in
reflex seizures and
refractory
seizures on awakening
symptomatic
valproic acid in
Generalized epilepsy with febrile seizures plus (GEFS+)
age of onset
basic mechanisms
clinical phenotypes
clinical presentation
definitions
development of
diagnostic evaluation
differential diagnosis
epidemiology
etiology
family history in
GABRG2 genes in
gene mutations in
genetic counseling in
genetic mutations in
genetics of
historical perspectives
outcomes
prognosis
SCN genes in
SNC1A mutations in
SNC1B mutations in
sodium channel mutations
spectrum of phenotypes
temporal lobe epilepsies and
treatment
Generalized hemiclonic seizures
anatomic pathways
clinical features
definitions
diagnostic considerations
electroencephalographic features
epidemiology
pathophysiology
specific syndromes
treatment
Generalized myoclonic epilepsy
Generalized myoclonic seizures
Generalized myoclonic—atonic seizures
Generalized seizures See also Generalized epilepsies
after stroke
animal models
in children
definition
EEGs
ictal electroencephalography
ILEA classification
Generalized spike-and-wave (GSW) activity
description
EEG
in normal children
patterns of
photoparoxymal responses and
Generalized status epilepticus
Generalized tonic–clonic seizures (GTCSs)
absence epilepsy and
with absences
adults with
anatomic pathways
on awakening
clinical features
ictal
postictal
complex partial status epilepticus and
complications
definitions
description
diagnostic considerations
differential diagnosis
EEG findings
ictal
interictal
pre-ictal
epidemiology
in generalized convulsive status epilepticus
in late-onset childhood occipital epilepsy (Gastaut type)
in myoclonus epilepsy with ragged-red fibers
in Panayiotopoulos syndrome
pathophysiology
patient identification
polygraphic recordings of
Premarin-provoked
primary versus secondary
primidone treatment in
reflex-induced
in renal failure
topiramate in
Generalized tonic–clonic seizures on awakening
Generalized tonic seizures
Generalized tonic–clonic seizures (GTCs)
Kcnc2 knockout mouse
Kcnc2 mutations and
myoclonus in
sleep deprivation and
uremia and
GeneTests
Genetic absence epilepsy rat of Strasbourg (GAERS)
Genetic counseling
approaches to
framework for
in malformations of cortical development
process of
Genetic disorders, epilepsy and
Genetic engineering
Genetic heterogeneity, principle of
Genetic models of epilepsy
Genetic polymorphisms
Genetic testing, ethical issues
Genetically epilepsy-prone rat (GEPR)
Genital pain, neocortical origin
Genomic integrity, principle of
Genomics, drug design and
Genotyping, high throughput
Gensat project
Genu, division of
GEPH gene mutations
Gephyrin, mutations in
GEPR 9 rats
Germany
access to care
for adults
for children
health services
hospitalization statistics
private insurance plans
state health insurance
employees with seizures
employment placement
general practitioners
health services
job access
national legislation
neurologist patient loads
pediatricians
psychogenic nonepileptic seizures
rehabilitation centers
sheltered employment
social welfare objectives
unemployment rates
vocational assessment
vocational rehabilitation
vocational training courses
Gerstmann’s syndrome
Geschwind syndrome See Interictal behavior syndrome
Gibbs, Erna
Gibbs, Frederick
Gilbert syndrome
Gilbertus Anglicus
Gilles de la Tourette syndrome (GTS)
Gillett, R v.
Gingival hyperplasia
Gingko, safety issues
Gitleman syndrome
P.I-25

Glanciclovir
Glasgow Coma Scale score
Glasgow Epilepsy Outcome Scale (GEOS)
GLAST See also EAAT1
glutamate control by
glutamate uptake and
neuron-glia interactions and
seizures and
GLI3 gene mutations
Gliadin
Glial cells
calcium ion waves
dysfunction
epileptogenesis and
focal epilepsies and
lactate production
proinflammatory cytokines in
synaptic plasticity and
Glial fibrillary acidic protein (GFAP)
expression of
immunohistochemistry
staining
Glial syncytium, connections
Glial tumors
Glioblastomas
cell culture from
epilepsy and
epileptogenic potential of
resection
Gliomas
astrocyte dysfunction and
epilepsy and
lesionectomy for
malignant
seizures and
surgical interventions
unresectable
Gliosis
focal epilepsies and
gangliogliomas and
neuromodulation by
reactive
seizures and
status epilepticus and
Global Burden of Disease (GBD) study
Global Campaign Against Epilepsy (GCAE) See also specific countries
creation of
goals of
launch
study of economic impacts
Globoid-cell leukodystrophy See Krabbe disease
Globus pallidus
basal ganglia circuits
external segment
GABAB receptors in
seizure-gating mechanisms
GLT-1 See also EAAT2
Glucocorticoids
Glucose
blood levels of
brain metabolism and
CSF concentration of
metabolism (See also Hyperglycemia; Hypoglycemia)
utilization of
Glucose transporter protein deficiency
Glucose transporter type 1 deficiency syndrome (GLUT-1 DS)
characterization
EEG findings
ketogenic diets in
seizures and
treatments
Glucuronyl transferases
GluR3 autoantibodies
GLUT1, in astrocytes
GLUT1 gene
Glutamate
calcium signaling and
cerebral development
developmental regulation
effect of antiepileptic drugs on
extracellular
genes encoding
hippocampal
metabolism of
neuronal excitability and
release during seizures
uptake
Glutamate receptors
alterations
autoantibodies to
inotropic
metabotropic (mGluRs)
mRNA editing mutations
seizures and
subunits
Glutamate transporters
Glutamic acid decarboxylase (GAD)
Glutamine
Glutamine synthetase
Glutaric acidemia type I
Glutaric aciduria, type I
Gluten, antibodies to
Glutethimide
Glutin-free diets
Glycine, levels of
Glycine encephalopathy
Glycogen storage diseases
Glycosylation, congenital disorders of
Glycyrrhizae Radix
GM1-gangliosides
GM2-gangliosidosis See also Tay-Sachs disease
Goal planning
Goldberg’s Anxiety and Depression Scale
Golgi cells, glutamate receptors
Gonadotrophin-releasing hormone (GnRH)
analogs
for central precocious puberty
effect of epilepsy on
secretion
Gonadotropins, function
Gorlin-Goltz syndrome See Nevus basal cell carcinoma syndrome
Goserelin therapy
Governments, health care delivery by
Gowers, William. R.
GPR56 gene
Graduate Hospital, Pester v.
Grand mal convulsions
Granule cells
cell loss
dispersion
glutamate receptors
life cycle
Granulomatous angiitis
Grapefruit juice
GRASS (gradient recalled echo acquisition at steady state)
Graves disease
Gray matter
connectivity
extrahippocampal atrophy
in Rasmussen encephalitis
in temporal lobe epilepsy
Greece, views of epilepsy
Grooved pegboard test
Group psychoeducation
Growth deficiencies
Growth factors
Growth hormone
Guanosine triphosphate cyclohydrolase deficiency
Gustatory aura continua
Gustatory auras
Gustatory seizures
Guvacine
GYKI 53773 (LY 300164, talampanel)
Gyrus cinguli